ISSN 1662-4009 (online)

ey0016.10-1 | (1) | ESPEYB16

10.1. Transition to adult diabetes care in Germany - high risk for acute complications and declining metabolic control during the transition phase

TM Kapellen , S Muther , A Schwandt , J Grulich-Henn , B Schenk , KO Schwab , W Marg , RW Holl

Pediatr Diabetes. 2018 Apr 25. doi: 10.1111/pedi.12687. [Epub ahead of print]Transition of patients with chronic diseases from pediatric to adult care has become recognized as an important part of health care provision and its multifaceted challenges are increasingly being studied. This transition period is associated with deterioration of metabolic control and general health in young adults wi...

ey0016.10-12 | (1) | ESPEYB16

10.12. Efficacy of growth hormone treatment in children with type 1 diabetes mellitus and growth hormone deficiency - An analysis of KIGS data

W Bonfig , A Lindberg , M Carlsson , W Cutfield , D Dunger , C Camacho-Hubner , RW Holl

To read the full abstract: J Pediatr. 2018 Jul;198:260–264This study aimed to analyze growth hormone (GH) doses and first-year growth response in prepubertal patients with the combination of type 1 diabetes (T1D) and growth hormone deficiency (GHD).A total of 69 patients with T1D and GHD treated with GH have been enrolled in KIGS (Pfizer International Growth D...

ey0015.4-2 | Important for clinical practice | ESPEYB15

4.2 Efficacy of growth hormone treatment in children with type 1 diabetes mellitus and growth hormone deficiency-an analysis of KIGS data

W Bonfig , A Lindberg , M Carlsson , W Cutfield , D Dunger , C Camacho-Hübner , RW Holl

To read the full abstract: J Pediatr 2018; 198: 260-264The incidence of T1DM in children <15 years is increasing at an overall annual relative rate of 3.9% (95% CI 3.6-4.2) [11]. The prevalence of GHD is estimated at approximately 1:4000 to 1:10000 [12-14]. Management of the very rare patients who have both T1DM and GHD raises questions of efficacy and safety of ...

ey0016.10-5 | (1) | ESPEYB16

10.5. Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial

M Ballmann , H Dominique , MA Baroukh , D Staab , A Hebestreit , L Naehrlich , T Nickolay , N Prinz , RW Holl

To read the full abstract: Lancet Diabetes and Endocrinology 2018; 6: 114–121Cystic fibrosis (CF)-related diabetes (CFRD) impacts significantly on mortality and quality of life. Impaired glucose metabolism and CFRD are associated with poor weight and height gain and impaired lung function in children and adolescents (1). In that study, height and weight were lower in CF patients wit...

ey0015.10-8 | Continuous glucose monitoring, insulin pumps and artificial pancreas | ESPEYB15

10.8 Association of insulin pump therapy vs insulin injection therapy with severe hypoglycemia, ketoacidosis, and glycemic control among children, adolescents, and young adults with T1DM

B Karges , A Schwandt , B Heidtmann , O Kordonouri , E Binder , U Schierloh , C Boettcher , T Kapellen , J Rosenbauer , RW Holl

To read the full abstract: JAMA. 2017;318:1358-1366Here, the authors compared the metabolic control in young patients with T1DM with insulin pump therapies versus multiple injection treatment modalities using the data from 30 579 patients younger than 20 years of age of 446 centers in a prospective population-based cohort study. While it is very clear that pump therapy, compared with injection ...

ey0018.10-1 | (1) | ESPEYB18

10.1. Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?

SR Tittel , J Rosenbauer , C Kamrath , J Ziegler , F Reschke , J Hammersen , K Monkemoller , A Pappa , T Kapellen , RW Holl , Initiative DPV

Diabetes Care. 2020;43(11):e172–e173. doi: 10.2337/dc20-1633During the first phase of the COVID-19 pandemic, the DPV (the German diabetes registry database) study group asked whether or not the COVID-19 lockdown had affected the incidence of pediatric T1D in Germany (1). More than 210 German pediatric diabetes centers contributed their data on pediatric patients with T1D with an onset at ag...

ey0016.10-7 | (1) | ESPEYB16

10.7. Worse metabolic control and dynamics of weight status in adolescent girls point to eating disorders in the first years after manifestation of type 1 diabetes mellitus: findings from the diabetes patienten verlaufsdokumentation registry

T Reinehr , B Dieris , A Galler , M Teufel , G Berger , R Stachow , S Golembowski , U Ohlenschlager , M Holder , M Hummel , RW Holl , N Prinz

To read the full abstract: J Pediatr. 2019;207:205–2129.Psychosocial issues and psychiatric disease are prevalent in young patients with type 1 diabetes (T1D). Most importantly, eating disorders, anxiety-related behavioral problems as well as depression have all been shown to occur (1). In a nationwide population-based survey, this group had previously reported on relationships betw...

ey0016.10-9 | (1) | ESPEYB16

10.9. Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative

DJ DeSalvo , KM Miller , JM Hermann , DM Maahs , SE Hofer , MA Clements , E Lilienthal , JL Sherr , M Tauschmann , RW Holl , Exchange DPV Registries T1D

To read the full abstract: Pediatr Diabetes. 2018;19:1271–1275New technologies such as continuous glucose monitoring, insulin pumps and closed-loop systems are likely to change diabetes care and hopefully will reduce the burden of disease management, decrease diabetes associated comorbidities, and increase life expectancy.To assess the change in rates of pedia...

ey0020.8-6 | Important for Clinical Practice | ESPEYB20

8.6. Continuous glucose monitoring versus blood glucose monitoring for risk of severe hypoglycaemia and diabetic ketoacidosis in children, adolescents, and young adults with type 1 diabetes: a population-based study

B Karges , SR Tittel , A Bey , C Freiberg , C Klinkert , O Kordonouri , S Thiele-Schmitz , C Schroder , C Steigleder-Schweiger , RW Holl

Brief summary: In this large registry-based study, including 32 117 children and young people (aged 1.5–25 years) with type 1 diabetes (T1D), the use of continuous glucose monitoring (CGM) was associated with decreased rates of diabetic ketoacidosis (DKA) and severe hypoglycemia. Of interest, some CGM metrics predicted risk for these complications.CGM systems are now widely used by children with T1D, and there is evidence both from clinical trials a...